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KMID : 1036520110010010039
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Clinical Neuro-Ophthalmology
2011 Volume.1 No. 1 p.39 ~ p.46
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Eye Findings in Neuro-muscular Diseases
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Huh Young-Eun
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Abstract
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Ocular myasthenia is a subtype of myasthenia gravis causing diplopia, ptosis, and weakness of lid closure. Clinically, ocular myasthenia can mimic any form of pupil-sparing ocular motility disorder. Dynamic abnormalities of myasthenic eye movements may reflect the primary hallmarks of the disease, which are fatigability and variability in strength, or secondary adaptive effects by the central nervous system. Ice, sleep, and rest tests are safe and inexpensive test for ocular myasthenia with high specificity and sensitivity. Abnormal eye movements are increasingly recognized in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. Disorders of saccade (slow saccade, delayed memory-guided saccade, inaccurate and delayed antisaccade), smooth pursuit (decreased gain), ocular fixation (increased saccadic intrusion amplitude), and ophthalmoplegia are reported in patients with ALS.
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KEYWORD
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Ocular myasthenia, Amyotrophic lateral sclerosis, Eye movement
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